2014-01-15

Co.Exist

Can Male Birth Control Save Humanity?

Population growth needs to be controlled. Could a pill for men be the solution?

Among the many tricks we will try to keep fitting ourselves onto this planet, there is one that we already know. The technology is cheaper than all the others by many orders of magnitude. It is reducing the numbers of bodies to feed by managing our reproduction, before nature steps in to do that for us.

It is not perfect technology: for a small percentage of women, the chemistry of contraception causes migraines or depression, although the copper‑T IUD is a benign alternative, easily reversible as long as a trained medical practitioner is handy. Those chemical effects are not confined solely to women’s bodies, because while nearly half of estrogen is metabolized, the rest is excreted. Flushed away, a portion is removed in sewage treatment, but the rest finds its way into the ecosystem.

Some of the gender-bending estrogens feminizing not just minnows but trout, bass, and perch in lakes and rivers worldwide are identical to the ones in oral contraceptives. In every big river of North America except the Yukon, female egg cells are now common in two-thirds or more of male largemouth and smallmouth bass. In several studies in the United States, Canada, and England, however, research indicates that, compared to industrial and agrochemical sources, female contraceptives are a minuscule part of the artificial hormonal assault on the environment.

That doesn’t mean that current technology needn’t be improved; however we can minimize chemical exposure to women and to the ecosystem, the better. Among the most promising options is to counter conception through a far simpler pathway: by short-circuiting male sperm delivery.

Two possibilities are male versions of the Pill, which, unlike their female counterparts, don’t manipulate hormones. One, already tested at Kansas State University on rats, rabbits, and monkeys, uses a compound called H2‑gamendazole that stops sperm from forming in men’s semen without reducing their sex drive, and is reversible within weeks. The other oral treatment uses a compound developed in the Bradner Laboratory at Boston’s Dana-Farber Cancer Institute called JQ1, which targets a testis-specific protein to lower sperm numbers and retard their swimming capability. Again, test mice show no lowered libidos, and regain fertility when they stop taking it.

Two of the most imaginative approaches aren’t chemical, but mechanical interventions. Risug--reversible inhibition of sperm under guidance--is already offered in several cities in India, and as of 2012 was in FDA trials in the United States. It involves a 15-minute outpatient operation using local anesthetic via a tiny incision in the scrotum to reach the vas deferens tube, into which the doctor injects an inexpensive polymer gel. Within three days, the gel forms a lining that allows semen to pass normally, but electrolytically destroys sperm. The spermicidal effect lasts for ten years, but can be reversed by injecting a baking soda solution. The same Indian developer has been testing another method at the University of North Carolina that uses ultrasound to heat testes for 15 minutes, resulting in six months of sterility in test animals.

Each of these techniques portends to be cheaper and safer both for humans and the environment than female chemical contraception. For a woman in a steady relationship with a willing partner, it could shift the stress of birth control from her uterus, conserving that organ for the sole use that nature intended. Reliance on male contraception would also, however, mean relinquishing control over her own reproduction, inserting a new test of trust into intergender dynamics. For men, it could mean liberation from the interruptive frustration of using condoms--although, outside of monogamy, there would be a loss of protection from sexually transmitted disease. As long as one epidemic that threatens human existence, HIV, is spread through seminal fluids, protection and contraception must remain related but separate issues.

For the world, simple, nontoxic male contraception would mean a powerful form of population restraint, one which would far more equitably share responsibility for planning families. The politicization of contraception, born of gender wars waged by extremist Catholic and evangelical Christians, fundamentalist Muslims, and ultra-Orthodox Jews, may be befuddled should anyone try prohibiting men from choosing whether to use it. Male pills and instantly reversible vasectomies will be interesting, welcome new elements in the complex mix of managing our future, even as we consummate our desires.

Excerpted from the book COUNTDOWN by Alan Weisman. Copyright © 2013 by Alan Weisman. Reprinted with permission of Little, Brown and Company. All rights reserved.

[Image: Banana condom via Shutterstock]

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4 Comments

  • Ref. your headline to this article, it's a myth that the world's population is out of control. See almost anything by Swedish medic and statistician Hans Rosling, including the various references to his programme for the BBC, Don't Panic – The Truth About Population.

  • Gepo Malmalla

    from this article one can think that RISUG is already available for some people in India. this is not the case. it is still in trials in India and only the ones that are part of the trial are getting it.

  • Christopher Moore

    In addition to the points made in the article, it would give men and teen boys much better agency to their reproductive rights. Something they desperately need.